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          Creating                                             76%          stated that without data shared on open
                                                                            repositories, they would not be able to offer
                                                                            their product or service.
          customer value                                       89%          stated that a product or service has more

                                                                            features because of access to shared or open
          from open data                                                    repositories.


                                                               63%          stated that without access to registries,
                                                                            ontologies, and dictionaries published on open
                                                                            repositories, they would not be able to offer
                                                                            their product or service.
          Ventures that operate in the bioinformatics sector
          can either cater for many different life science
                                                               92%          features because of access to registries,
          application areas or be highly specialised and                    stated that a product or service has more
          focused. We have surveyed a range of companies in                 ontologies, and dictionaries shared on open
          this sector to understand how they operate, which                 repositories.
          public resources they use in their business and how
          they contribute to the economy.
                                                              the European Genome-Phenome Archive (EGA)), as
          Our survey of over 50 bioinformatics SMEs has       well as open software or algorithmic workflows.
          indicated that all surveyed companies use openly
          available resources, such as data, software or      68% of respondents indicated that large scale data
          standards at varying degrees to create value for    analysis lies at the core of their services, and 62%
          clients. Figure 3 gives a general overview of firms   considered access to open software to be critical
          operating in this industry segment. Business input   for doing their business efficiently. Our survey
          can consist of open data, such as publications (e.g.   confirmed the importance of open resources for
          from Europe PMC), protein sequence information      bioinformatics companies to improve existing or
          (e.g. from UniProt), or genome sequences (e.g. from   develop new products and services.




            Input examples                                                                   Output examples

                  Organism

                  Protein
                                                                                                   Diagnostic
                  Genomics                                                                         tests
                  Data
          Public data  Transcript                                                                  New drugs
                                                                                                   and vaccines
                  Publications

                  Patents                                                                          Cosmetics
                                                                                                   Animal food
                  Variants
                  Active                                                                           Washing
                  substances                                                                       powders
                                                           Business internal
                                                         appropriation strategies                  Medical
                                                         using expert knowledge                    devices
                                                            or technologies                        Technology
          Proprietary data  Data &                                                                 solutions
                                                            such as AI/ML
             other
             resources





          Figure 3. Bioinformatics companies often combine open and proprietary resources
          to generate a product or service.
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