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          Abstract






                                                               Openness in the life sciences
          ‘In the long history of
                                                               facilitates collaboration
          humankind (and animal
          kind, too) those who learned                         and increases innovation

          to collaborate and improvise                         potential for industry

          most effectively have
                                                               Undoubtedly,  at one point in their career, every
          prevailed.’                                          scientist will come across the work of Charles
                                                               Darwin and his groundbreaking discoveries
                                                               and theories. Already in 1859, he argued that
                                           Charles Darwin      collaborative use and reuse of existing resources
            The Origin of Species by Means of Natural Selection, or the   enable novel outcomes. His work has been regularly
           Preservation of Favoured Races in the Struggle for Life, 1859       used to explain success through innovation and
                                                               entrepreneurship.

                                                               Two centuries later we have numerous examples
                                                               that prove this is true – scientific discovery
                                                               and groundbreaking products never appear on
                                                               green fields in isolation, they are underpinned by
                                                                                          1
                                                               knowledge generated by others .
                                                               But how can we foster these collaborative
                                                               environments and what are the key components
                                                               of success, particularly after years of digital
                                                               transformation in the life science sector?

                                                               Our research has shown that access to open,
                                                               free resources, such as data and software, is the
                                                               underlying basis for breakthrough discoveries,
                                                               scientific excellence and entrepreneurial
                                                               endeavours.

                                                               Translating zeros and ones into real-world
                                                               medicines, food or energy sources has become
                                                               a cornerstone of economic activity, promising
                                                               benefits for societies across the globe. To realise
                                                               this potential, we need to understand the economic
                                                               environment in the life sciences today and the
                                                               actors therein, including entrepreneurs that bridge
                                                               academia and industry, companies that use open
                                                               resources and public infrastructure providers that
                                                               engage in public-private partnerships.










                                                               1  Mariana Mazzucato. The Entrepreneurial State: Debunking Public vs. Private
                                                                Sector Myths. (Penguin, 2018).
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