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                                                            Methods






                                                            This report has been based on the qualitative-
                                                                               20
                                                            exploratory field study  conducted in 2018-2019 to
                                                            understand the challenges that digital entrepreneurs
                                                            face to appropriate value from bio-data infrastructures.

                                                            Further, an open questionnaire with 54 participating
                                                            bioinformatics companies was used to get a deeper
                                                            understanding of business models, scalability
                                                            and resources of importance. Databases, such as
                                                            Crunchbase, Thomson Reuters, Dealroom, Amadeus
                                                            and LinkedIn, were used to support this report and
                                                            complement the field studies. The ecosystem analysis
                                                            presented in this report focused on SMEs that have
                                                            been founded after 2001, and that have neither been
                                                            dissolved nor sold or integrated into large corporations.

                                                            Complementary to our own data and analysis, this
                                                            report also refers to insights from the ‘Regional
                                                                                      21
                                                            Innovation Scoreboard (RIS)’ , which provides a
                                                            comparative assessment of the regional research and
                                                            innovation performance of the EU Member States
                                                            and the relative strengths and weaknesses of their
                                                            innovation ecosystems.

                                                            Together, we compared our results to explain
                                                            the attractiveness of individual ecosystems for
                                                            bioinformatics companies within each ecosystem.

































                                                            20  Rothe, H., Jarvenpaa, S. & Penninger, A. How do entrepreneurial firms
                                                               appropriate value in bio data infrastructures: an exploratory qualitative study.
                                                               Res. Pap. (2019).
                                                            21  Regional innovation scoreboard | Internal Market, Industry, Entrepreneurship
                                                               and SMEs. https://ec.europa.eu/growth/industry/policy/innovation/regional_en.
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