Services: Genes and genomes

We provide support and guidance in development of Disease Maps (disease-maps.org), computational and visual repositories of knowledge about mechanisms of human diseases. We offer hosting of open access Disease Maps on the MINERVA Platform (minerva-web.lcsb.uni.lu) on our infrastructure under the elixir-luxembourg.org sub-domain, their backup and conservation. The MINERVA Platform ensures online access, interactive exploration, search for known drug targets and visualisation of omics datasets. We provide training in management of the Disease Maps and guidance to their integration into reproducible computational workflows by using the dedicated API of the hosting platform.

Web interface for assignment and analysis of DNA conformers.

Database Of Local Biomolecumal COnfromers. (Formerly known as DOLCE)

The Electron Microscopy Public Image Archive, is a public resource for raw, 2D electron microscopy images.

Produces and maintains automatic and manually curated annotation on eukaryotic genomes. It is integrated with important molecular resources, for example UniProt, and can be accessed programmatically or through a web browser.

Provides annotated genomes of farmed and domesticated animals in an easily viewable format via the Ensembl system.

Provides access to genome-scale data from bacteria, protists, fungi, plants and invertebrate metazoa, through a unified set of interactive and programmatic interfaces based on the Ensembl software platform.

Enterotypes are densely populated regions in a high-dimensional space of microbiome community composition, by which human individuals can be stratified. Computational methods to detect and characterise enterotypes in any dataset, either to reproduce previous reports or determine enterotypes in new studies, are provided and explained. Part of the Microbiome Analysis Toolbox. 

An annotated non-redundant collection of eukaryotic POL II promoters, for which the transcription start site has been determined experimentally. Pointers to positions in nucleotide sequence entries provide access to promoter sequences. 

European Variation Archive

The Expression Atlas allows users to search for gene expression changes measured in various cell types, organism parts, and disease states. It represents a curated subset of the ArrayExpress and GEO Archive experiments.

FAIDARE is a portal developed by ELIXIR-FR as an asset of the ELIXIR Plant Science community. FAIDARE enables data discovery through federations of distant Plant informations systems that have set up a standardized Restful API, the BrAPI. FAIDARE currently allows to do detailed searches of accessions and phenotyping data.

Database and web portal for genetic and genomic information on fruit fly Drosophila melanogaster and related fly species.

Web application for the integrative and combined analysis and visualization of multi-level omics data. (Replaced ProMeTra)

An optimized pipeline of MuTect and GATK tools to improve the detection of somatic single nucleotide polymorphisms in whole-exome sequencing data.

Prokaryote genome annotation system, modular, flexible and extensible.

Eukaryotic genome annotation system, modular, flexible and extensible.

The Gene Ontology (GO) project addresses the need for consistent descriptions of gene products across databases. It has developed three structured, controlled vocabularies (ontologies) that describe gene products.

The South Green Genome Hub is a suite of crop-specific community portals to manage genomic datasets with focus on tropical and Mediterranean plants. Currently developed on Banana, Cassava, Cacao, Coffee, Grass, Rice and Sugarcane, genome hubs provide access to multiple datasets (e.g. assemblies, gene product information, metabolic pathways, gene families, transcriptomics and genetic markers).

Genomicus is a database and a web server that integrates comparative genome data and ancestral genome reconstruction in a fast and intuitive way. It enables users to navigate in genomes in several dimensions: linearly along chromosome axes, transversaly across different species, and chronologicaly along evolutionary time. A user-friendly graphical interface allows syntenic comparisons and gene order alignments between pairs of genomes or multiple genomes at different scales: local gene order, karyotypes, matrix plots, etc.  Different phylums such as Vertebrates, Plants, Fungi, Metazoa (as per Ensembl Genomes) are represented and regularly updated, as well as specific versions on Tunicates, Fish and Amphioxus.  

GnpIS is an interoperable Information System for plant and pest genomics. It is a powerful multispecies centralized information system with seven linked relational databases. 

The UniProt  GO annotation program (GOA) aims to provide high-quality Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB).

The NHGRI-EBI GWAS Catalog is a quality-controlled, manually curated, literature-derived collection of all published genome-wide association studies.
 

Performs haplotype assembly from long gapless reads.

Human Endogenous RetroViruses Database.

HUGO Gene Nomenclature Committee, responsible for approving unique symbols and names for human loci, including protein coding genes, ncRNA genes and pseudogenes, to allow unambiguous scientific communication.

Database of human mitochondrial genomes from primary INSDC databases, personal submissions and application of MtoolBox to NGS data.

A collection of web resources for working with proteins, drug reactions, gene expression analysis, proteome profiling and assessing MinION Data, including: 

• DeSeq2 - an R/Bioconductor package for differential expression analysis of high-throughput sequencing assays
• DexSeq - an extension of DESeq for the analysis of alternative exon usage.
• EBImage - R/Bioconductor package that provides general purpose functionality for the reading, writing, processing and analysis of images.
• SMART - a web resource providing simple identification and extensive annotation of protein domains via sequence homology searches.
• SIDER - a web-based resource that contains information on marketed medicines and their recorded adverse drug reactions.

A population-based database that collects all the cases with malignancies in Hungary by reports of oncology care hospitals. Registration is mandatory. The Registry is regulated by the order of the Hungarian Government and maintained by the  National Institute of Oncology.

ionomicHUB provides curated ionomic data on many thousands of plant samples freely available to the public. It is an international collaborative cyber research environment to help identify and understand the genes and gene networks that function to control the ionome, the mineral nutrient and trace element composition of an organism or tissue.