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Name Description ELIXIR Node
A microbial metabolism resource for Systems Biology

The microbial world provides an abundant source of biological catalysts for chemicals of medical and economic interest such as pharmaceuticals and biofuels. However, a sustainable resource for systems biology, that integrates experimental and predicted data on microbial metabolism, is still lacking. This Implementation Study defines the requirements for a European Bioinformatics resource for microbial metabolism as well as providing a practical demonstration of how existing funded resources from ELIXIR partners could be integrated to meet those needs.

This Study brings together complimentary data types:

  • microbial genomes and genes
  • protein function annotation
  • enzymatic reactions
  • metabolic pathways
  • metabolic models

These connections via RDF standards have many underpinning implications in medicine and economy such as pharmaceuticals and biofuels.

This study has now been completed, the end report is available here.

An article in the ELIXIR F1000R gateway will be made available shortly. 

Webinar summarising the outcomes

ELIXIR Switzerland, ELIXIR France, EMBL-EBI
A microbial metabolism resource for Systems Biology

The microbial world provides an abundant source of biological catalysts for chemicals of medical and economic interest such as pharmaceuticals and biofuels. However, a sustainable resource for systems biology, that integrates experimental and predicted data on microbial metabolism, is still lacking. This Implementation Study defines the requirements for a European Bioinformatics resource for microbial metabolism as well as providing a practical demonstration of how existing funded resources from ELIXIR partners could be integrated to meet those needs.

This Study brings together complimentary data types:

  • microbial genomes and genes
  • protein function annotation
  • enzymatic reactions
  • metabolic pathways
  • metabolic models

These connections via RDF standards have many underpinning implications in medicine and economy such as pharmaceuticals and biofuels.

This study has now been completed, the end report is available here.

An article in the ELIXIR F1000R gateway will be made available shortly. 

Webinar summarising the outcomes

ELIXIR Switzerland, ELIXIR France, EMBL-EBI
A microbial metabolism resource for Systems Biology

The microbial world provides an abundant source of biological catalysts for chemicals of medical and economic interest such as pharmaceuticals and biofuels. However, a sustainable resource for systems biology, that integrates experimental and predicted data on microbial metabolism, is still lacking. This Implementation Study defines the requirements for a European Bioinformatics resource for microbial metabolism as well as providing a practical demonstration of how existing funded resources from ELIXIR partners could be integrated to meet those needs.

This Study brings together complimentary data types:

  • microbial genomes and genes
  • protein function annotation
  • enzymatic reactions
  • metabolic pathways
  • metabolic models

These connections via RDF standards have many underpinning implications in medicine and economy such as pharmaceuticals and biofuels.

This study has now been completed, the end report is available here.

An article in the ELIXIR F1000R gateway will be made available shortly. 

Webinar summarising the outcomes

ELIXIR Switzerland, ELIXIR France, EMBL-EBI
Data and knowledge management in an automated enzyme characterisation workflow: an industry perspective

Advancements in biological system engineering have introduced new data challenges in biotechnology. These challenges are even more pronounced when high-throughput robotic systems are used in screening and manufacturing. While academic projects and use cases have enabled progress in data management, industrial systems face distinct challenges related to data sharing, security, and process verification. This project aims to investigate industrial data sharing challenges.

 As part of the Microbial Biotechnology Community, a recent joint implementation study between Newcastle and Manchester ELIXIR Nodes explored the data management requirements of biotechnology. This effort resulted in published guidelines in collaboration with the RDMkit team (https://rdmkit.elixir-europe.org/). The study was extended to consider an automated hybrid in-vitro/in-silico workflow designed to characterise recombinant enzymes and their protein families, with a particular focus on understanding their data characteristics in an academic setting (see figure below).

Workflow to characterise recombinant enzymes and their protein families

Prozomix Ltd., an SME specializing in enzyme-based biocatalysts, is using high-throughput systems to identify novel members of enzyme protein families, within the company and in collaboration with academic partners. This project proposes a technology transfer process from academia to industry, involving the adaptation and deployment of the automated pipeline at Prozomix.

A data requirements analysis will address the specific data challenges faced by the industry, identifying the points at which data could be shared without undermining the company’s intellectual property. The ultimate goal is to develop generic guidelines for industrial partners to make their data FAIR (Findable, Accessible, Interoperable, and Reusable) without compromising intellectual property and data security.

The project's anticipated outcomes include fostering collaboration between the ELIXIR communities and industry, encouraging academic members to explore more commercially focused use cases, and industrial members to think about FAIR data. Additionally, the project aims to highlight the differences in FAIR data needs between industry and academia and create a generic framework to facilitate data sharing in industrial biotechnology.

ELIXIR UK
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI
Microbial Biotechnology Community

A formal framework for microbial biotechnology to manage and manipulate strains, samples, knowledge, data and metadata is still lacking. The Design - Build - Test - Learn (DBTL) cycle provides a conceptual framework for the development of tailor-made microbes and biological systems. The ELIXIR Microbial Community takes the DBTL cycle as a starting point for defining its four key objectives.

This implementation study builds upon the F1000 position paper for the Microbial Community and will revolve around three core, closely intertwined activities: Enzymes, Models and Ontologies & Workflows. All are embedded in a Training framework and relate directly to the Platforms Data, Tools, Interoperability and Training.

ELIXIR Netherlands, ELIXIR France, ELIXIR UK, ELIXIR Greece, ELIXIR Finland, ELIXIR Germany, ELIXIR Portugal, ELIXIR Slovenia, ELIXIR Switzerland, EMBL-EBI